Cell-to-Cell Communication [Paperback]

1 Gap Junction Structure.- 1. Introduction.- 2. Classification of Gap Junctions.- 3. Morphological Characterization of Type I Gap Junctions.- 3.1. Conventional Electron Microscopy.- 3.2. Quaternary Organization of the Gap Junction Channel.- 3.3. Possible Conformational Changes Involved in Gating.- 4. Morphological Characterization of Type II Gap Junctions.- 5. Morphological Characterization of Type III Gap Junctions.- 6. Conclusions.- 7. References.- 2 Modulation of Junctional Permeability.- 1. Introduction: Physiological Considerations.- 2. Are Gap Junctions Really Involved in Cell-to-Cell Communication?.- 3. Junctional Permeability.- 3.1. On the Regulation of Junctional Permeability.- 3.2. Na/Ca Exchange and Metabolic Inhibitors Alter the Electrical Coupling.- 3.3. Is Calcium a Physiological Modulator of Junctional Permeability?.- 3.4. Influence of Protons on Cell-to-Cell Communication.- 3.5. Cyclic AMPA Physiological Regulator of Junctional Permeability?.- 4. Synaptic Transmission and Cell-to-Cell Coupling.- 5. Voltage Dependence.- 6. Antibodies.- 7. Influence of Temperature on gj.- 8. Pathological Implications of Junctional Conductance.- 8.1. Increased Junctional ResistanceA Cause for Slow Conduction, Reentry, and Cardiac Arrhythmias.- 8.2. Uncoupling Leads to Decreased Strength of Heartbeat.- 9. Conclusions.- 10. References.- 3 Permeability and Regulation of Gap Junction Channels in Cells and in Artificial Lipid Bilayers.- 1. Introduction.- 2. Evidence for Cell-to-Cell Channels at Gap Junctions.- 2.1. Structural Data.- 2.2. Structure-Function Studies.- 2.3. Data from Intracellular Injection of Antibodies to Gap Junctions.- 2.4. Junctional Proteins Make Channels in Artificial Lipid Systems.- 3. Cell-to-Cell Channel Gating and Permeability Modulation.- 3.1. Uncouplers.- 3.2. Uncoupling Intermediates.- 4. References.- 4 Electrotonic Coupling in the Nervous System.- 1. Introduction.- 2. Electrotonic Inhibition.- 3. Modulation of Electrotonic Coupling.- 3.1. Voltaló$