The completion of the first draft of the human genome has led to an explosion of interest in genetics and molecular biology. The view of the genome as a network of interacting computational components is well-established, but researchers are now trying to reverse the analogy, by using living organisms to construct logic circuits. The potential applications for such technologies is huge, ranging from bio-sensors, through industrial applications to drug delivery and diagnostics. This book would be the first to deal with the implementation of this technology, describing several working experimental demonstrations using cells as components of logic circuits, building toward computers incorporating biological components in their functioning.
Contributors Theoretical and Engineering Principles 1. An Introduction to Cellular Computing,Martyn Amos and Gerald Owenson 2. Proteins and Information Processing,Ray Paton, Michael Fisher, Grant Malcolm, and Koichiro Matsuno 3. Enzyme Genetic Programming,Michael A. Lones and Andy M. Tyrell 4. Genetic Process Engineering,Ron Weiss, Thomas F. Knight Jr., and Gerald Sussman 5. The Device Science of Whole Cells as Components In Microscale and Nanoscale Systems,Michael L. Simpson, Gary S. Sayler, James T. Fleming, John Sanseverino, and Chris D. Cox Laboratory Experiments 6. TheEnterococcus faecalisInformation Gate,Kenichi Wakabayashi and Masayuki Yamamura 7. Cellular Computation and Communication Using Engineered Genetic Regulatory Networks,Ron Weiss, Thomas F. Knight Jr., and Gerald Sussman 8. The Biology of Integration of Cells into Microscale and Nanoscale Systems,Michael L. Simpson, Timothy E. McKnight, Michael A. Guillorn, Vladimir I. Merkulov, Gary S. Sayler, and Anatoli Melechko Computation in Ciliates 9. Encrypted Genes and Their Assemblylc7