This study assembles the available evidence for the poorly documented area of knowledge of the chemical arts in pre-Columbian America, finding this to be more extensive than is often assumed. Topics and processes discussed include food preparation and preservation, drugs and poisons, dyeing, tanning, embalming andmetallurgy amongst others.This study assembles the available evidence for the poorly documented area of knowledge of the chemical arts in pre-Columbian America, finding this to be more extensive than is often assumed. Topics and processes discussed include food preparation and preservation, drugs and poisons, dyeing, tanning, embalming andmetallurgy amongst others.