Chemoradiation in Cancer Therapy [Paperback]

Internationally recognized experts in cancer biology and clinical research review the present status of the multimodality approach to the management of solid tumors and speculate on possible future strategies for chemoradiation therapy. The authors detail applications of combined modality therapy in lung, esophageal, breast, gastric, pancreatic, colon, and rectal cancers. They also show how radiation interacts with such chemotherapeutic agents as the platinum complexes, taxanes, and gemcitabine in the treatment of malignant gliomas, and head and neck cancer. A review of how to integrate new specific molecular targeted agents into multimodality therapy in the future.Internationally recognized experts in cancer biology and clinical research review the present status of the multimodality approach to the management of solid tumors and speculate on possible future strategies for chemoradiation therapy. The authors detail applications of combined modality therapy in lung, esophageal, breast, gastric, pancreatic, colon, and rectal cancers. They also show how radiation interacts with such chemotherapeutic agents as the platinum complexes, taxanes, and gemcitabine in the treatment of malignant gliomas, and head and neck cancer. A review of how to integrate new specific molecular targeted agents into multimodality therapy in the future.Part I. General/BackgroundChemoradiation: Biological Principles and PerspectivesHak Choy and Robert M. MacRaeFluoropyrimidines as Radiation SensitizersMuhammad Wasif Saif and Robert B. DiasioPart II. Mechanisms of Interaction of Specific Chemotherapeutic Agents with RadiationThe Role of Platinum Complexes in Combined Modality TherapyBeverly A. TeicherTaxanes in Combined Modality TherapyRobert M. MacRae and Hak ChoyCamptothecin Radiation SensitizationTyvin A. RichThe Role of Gemcitabine in Combined Modality TherapyJerome Landry, William Blackstock, Robert M. MacRae, Gary Yang, and Hak ChoyPart III. Clinical ApplicationsChemoradiation Strategies l£–