Chemosensitivity Volume II In Vivo Models, Imaging, and Molecular Regulators [Hardcover]

A state-of-the art collection of readily reproducible laboratory methods for assessing chemosensitivity in vitro and in vivo, and for assessing the parameters that modulate chemosensitivity in individual tumors. Chemosensitivity,Volume 2: In Vivo Models, Imaging, and Molecular Regulators contains cutting-edge protocols for classifying tumors into response categories and for customizing therapy to individuals. These readily reproducible techniques allow measurements of DNA damage, apoptotic cell death, and the molecular and cellular regulators of cytotoxicity, as well as in vivo animal modeling of chemosensitivity. A companion volume, Volume 1: In Vitro Assays contains in vitro and in vivo techniques to identify which new agents or combination of agents are effective for each type of tumor.A state-of-the art collection of readily reproducible laboratory methods for assessing chemosensitivity in vitro and in vivo, and for assessing the parameters that modulate chemosensitivity in individual tumors. Chemosensitivity,Volume 2: In Vivo Models, Imaging, and Molecular Regulators contains cutting-edge protocols for classifying tumors into response categories and for customizing therapy to individuals. These readily reproducible techniques allow measurements of DNA damage, apoptotic cell death, and the molecular and cellular regulators of cytotoxicity, as well as in vivo animal modeling of chemosensitivity. A companion volume, Volume 1: In Vitro Assays contains in vitro and in vivo techniques to identify which new agents or combination of agents are effective for each type of tumor.Part I. Measurements of DNA Damage, Cell Death, and Regulators of CytotoxicityIn Vitro Micronucleus Technique to Predict ChemosensitivityMichael FenechCell Cycle and Drug SensitivityAslamuzzaman Kazi and Q. Ping DouTUNEL Assay as a Measure of Chemotherapy-Induced ApoptosisRobert WiederApoptosis Assessment by the DNA Diffusion AssayNarendra P. SinghPARP Cleavage and Caspase Activity to Assess Chemol#