Cholecystokinin Antagonists in Gastroenterology Basic and Clinical Status [Paperback]

A new presentation of physiological regulatory mechanisms and therapeutic applications is given in this book. It represents a collection of the most up-to-date information in cholecystokinin (CCK) research, especially focusing on the development and characterization of CCK antagonists. The book contains chapters on the synthesis, biochemical and pharmacological characterization of potent and selective CCK antagonists as well as physiological applications of these compounds. The last section of the book is devoted to the involvement of CCK in pathological states and potential clinical applications of CCK antagonists.A new presentation of physiological regulatory mechanisms and therapeutic applications is given in this book. It represents a collection of the most up-to-date information in cholecystokinin (CCK) research, especially focusing on the development and characterization of CCK antagonists. The book contains chapters on the synthesis, biochemical and pharmacological characterization of potent and selective CCK antagonists as well as physiological applications of these compounds. The last section of the book is devoted to the involvement of CCK in pathological states and potential clinical applications of CCK antagonists.I: Biology of CCK.- Biochemistry of CCK.- The Morphological Localization of Cholecystokinin and Its Binding-Sites in the Diffuse Neuroendocrine System.- Heterogeneity of CCK Receptors: Classification and Characterization.- Biological Actions of CCK in the Gastrointestinal Tract.- Biological Actions of CCK in the Central Nervous System.- Vagally Mediated Actions of CCK.- II: Chemistry of CCK Antagonists.- Pentanoic Acid Derivatives.- Characterization of MK-329.- Boc-Tyr(SO3H)-Nle-Gly-Trp-Nle-Asp-2-Phenylethyl Ester  JMV180: A Unique CCK Analogue with Different Actions on High- and Low-Affinity CCK Receptors.- III: Physiological Application of CCK Antagonists.- Cholestokinin Receptor Antagonists In Vitro.- Effects of Cholecystokinin Receptor AntlC(