This book provides the reader with a contemporary and comprehensive overview about the molecular, cellular and system-wide principles of circadian clock regulation. Emphasis is placed on the importance of circadian clocks for the timing of therapeutic interventions.
Preface.- Part I.-?Molecular and cellular basis of circadian clocks.-?Molecular components of the mammalian circadian clock. The epigenetic language of circadian clocks. Peripheral circadian oscillators in mammals. The clock in the brain - neurons and networks in daily rhythms. Entrainment of circadian clocks.- Part II.-?Circadian control of physiology and behavior.- Circadian clocks and metabolism. Circadian control of the immune system. The circadian control of sleep. Circadian clocks in mood-related behaviors.- Part III.-?? Chronopharmacology and chronotherapy.- The role of clock genes in pharmacology. Circadian timing in cancer treatments. Pharmacological modulators of the circadian clock as potential therapeutic drugs. The circadian system in shift-workers.- Part IV.-?Systems biology of circadian clocks.- Mathematical modeling of circadian clocks. Transcriptional circuits in the mammalian circadian oscillator. Genome-wide analyses of circadian systems
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A timely book about the widespread impact of circadian clocks
For a broad readership in both basic science but also translational and clinical medicine
Written by leading authorities in the field
NL
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