Computational Modeling of Drugs Against Alzheimers Disease [Hardcover]

This volume describes different computational methods encompassing ligand-based approaches (QSAR, pharmcophore), structure-based approaches (homology modeling, docking, molecular dynamics simulation), and combined approaches (virtual screening) with applications in anti-Alzheimer drug design. Different background topics like molecular etiologies of Alzheimers disease, targets for new drug development, and different cheminformatic modeling strategies are covered for completeness. Special topics like multi-target drug development, natural products, protein misfolding, and nanomaterials are also included in connection with computational modeling of anti-Alzheimer drug development. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.?

Cutting-edge and authoritative, Computational Modeling of Drugs Against Alzheimers Disease is a valuable resource for learning about the latest computational techniques used to study this disease.?

Preface&
Table of Contents&
Contributing Authors&

Part I An Introduction to the Disease

1. Alzheimers Disease Therapy: Present and Future Molecules
Awanish Kumar and Ashwini Kumar

Part II Computational Modeling Methods for Anti-Alzheimer Agents

2. Recent Advances in Computational Approaches for Designing Potential Anti-Alzheimers Agents
Sergi G?mez-Ganau, Jes?s Vicente de Juli?n Ortiz, and Rafael Gozalbes

3. Computer-Aided Drug Design Approaches to Study Key Therapeutic Targets in Alzheimers Disease
Agostinho Lemos, Rita Melo, Irina S. Moreira and M. Nat?lia D. S. Cordeiro

4. Virtual Screening in the Search of New and Potent Antlc$