This volume introduces the reader to the latest experimental and bioinformatics methods for DNA sequencing, RNA sequencing, cell-free tumour DNA sequencing, single cell sequencing, single-cell proteomics and metabolomics. Chapters detail advanced analysis methods, such as Genome-Wide Association Studies (GWAS), machine learning, reconstruction and analysis of gene regulatory networks and differential coexpression network analysis, and gave a practical guide for how to choose and use the right algorithm or software to handle specific high throughput data or multi-omics data. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Authoritative and cutting-edge, Computational Systems Biology: Methods and Protocols aims to ensure successful results in the further study of this vital field.?
1. DNA Sequencing Data Analysis
Keyi Long, Lei Cai, and Lin He
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2. Transcriptome Sequencing: RNA-seq
Hong Zhang, Lin He, and Lei Cai
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3. Capture Hybridization of Long-range DNA Fragments for High-throughput Sequencing
Xing Chen, Gang Ni, Kai He, Zhao-Li Ding, Gui-Mei Li, Adeniyi C. Adeola, Robert W. Murphy, Wen-Zhi Wang, and Ya-Ping Zhang
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4. The Introduction and Clinical Application of Cell-free Tumour DNA
Jun Li, Renzhong Liu, Cuihong Huang, and Mingyan Xu
? 5. Bioinformatics Analysis for Cell-free Tumor DNA Sequencing Data
Shifu Chen, Ming Liu, and Yanqing Zhou
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6. An Overview of Genome-Wide Associationlóâ
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