CRISPR-Cas Systems RNA-mediated Adaptive Immunity in Bacteria and Archaea [Paperback]

CRISPR/Cas is a recently described defense system that protects bacteria and archaea against invasion by mobile genetic elements such as viruses and plasmids. A wide spectrum of distinct CRISPR/Cas systems has been identified in at least half of the available prokaryotic genomes. On-going structural and functional analyses have resulted in a far greater insight into the functions and possible applications of these systems, although many secrets remain to be discovered.

In this book, experts summarize the state of the art in this exciting field.

This book surveys research on a wide range of newly identified CRISPR-Cas systems, which defend bacteria and archaea against viruses and plasmids. Includes structural and functional analyses offering new insight into their functions and possible applications.

Discovery and seminal developments in the CRISPR field.- Occurrence, diversity of CRISPR-Cas systems and genotyping implications.- ?Evolution and classification of CRISPR-Cas systems and Cas protein families.- Regulation of CRISPR-based immune responses.- crRNA Biogenesis.- Distribution and mechanism of the Type I CRISPR/Cas Systems.- Type II  Streptococcus thermophilus.- Type III CRISPR-Cas Systems and the Roles CRISPR-Cas in Bacterial Virulence.- CRISPR-Cas Systems to Probe Ecological Diversity and Host-Viral Interactions.- Roles of CRISPR in regulation of physiological processes.- Applications of the versatile CRISPR-Cas systems.- CRISPRs in microbial community context.

CRISPR-Cas is a recently discovered defense system which protects bacteria and archaea against invasion by mobile genetic elements such as viruses and plasmids. A wide spectrum of distinct CRISPR-Cas immune systems has been identified in at least half of the available prokaryotic genomes. On-going biochemical and functional analyses have resulted in substantial insight into the functions and possible applicationl€