Cytochrome P450 2E1 Its Role in Disease and Drug Metabolism [Paperback]

The book deals with various clinical aspects of cytochrome P450 2E1 (CYP2E1) which is a potent source for oxidative stress. Oxidative stress is critical for pathogenesis of diseases and CYP2E1 is a major contributor for oxidative stress. Several clinical disorders are associated with changes in regulation of CYP2E1 and the consequent abnormalities which include alcoholic liver disease, alcoholic pancreatitis, carcinogenesis, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, obesity, hepatitis C virus infection, reproductive organ toxicity, hepatocellular and cholestatic liver cirrhosis, inhibition of bone repair, cross-tolerance in smokers and people treated with nicotine, disorders of central nervous system, changes in metabolism of protoxicants in the circulatory system and susceptibility to human papillomavirus infection. Hence, CYP2E1 emerges as a new and potent player in aggravating injury and furthering disease complications.The book examines clinical aspects of cytochrome P450 2E1(CYP2E1), covering clinical disorders associated with changes in the regulation of CYP2E1 and consequent abnormalities including alcoholic liver disease, hepatitis C, inhibition of bone repair and more.List of Contributors.- Preface.- Acknowledgements.- Chapter 1 Cytochrome P450 2E1 and its clinical aspects: an introduction and a brief perspective on the current research scenario, Aparajita Dey.- 1.1 Introduction.- 1.1.1 Purification and characterization of CYP2E1.- 1.1.2 The role of CYP2E1 as a potent source for oxidative stress.- 1.1.3 CYP2E1 and ethanol-mediated oxidative stress.- 1.1.4 Importance of CYP2E1 in health and disease.- 1.2 Research studies elucidating the role of CYP2E1 in disease and drug metabolism.- 1.3 Conclusions.- Chapter 2 Nrf2 and antioxidant defense against CYP2E1 toxicity, Arthur I Cederbaum.- 2.1 Introduction.- 2.2 Systems Producing ROS.- 2.2.1 Protection against ROS toxicity.- 2.2.2 Alcohol, oxidative stress, and cell injury.- 2.3 CYP2E1.- 2ld