Cytokines and the Liver [Hardcover]

Cytokines are synthesized and secreted in the liver by Kupffer cells, and are important for inflammation processes, the non-specific immune response, and probably the destruction and removal of tumour cells. The production of signal substances such as tumour necrosis factor-alpha, interleukin 1 and 6, and interferon alpha/beta is regulated by a complex set of pathways, which can also be modified by cellular mediators, e.g. prostaglandins, growth factors and cortico-steroids. Signal exchange between different cell types in the liver is important for the synthesis of acute phase proteins, liver fibrosis, permeability and liver regeneration. This has clinical implications for hepatitis, cirrhosis and liver transplantation.
This book contains the proceedings of the 78th Falk Symposium (Part II of the Gastroenterology Week, Freiburg, 1994) held on 15--16 June and brings together clinicians and researchers worldwide to discuss the role of cytokines in hepatology.
Introduction. Part A: Cytokines and their Receptors in the Liver. Section 1: Regulation of Synthesis. 1. Cytokine response to infection; A. Cerami. 2. Interleukin-8 and other chemokines: new perspectives in inflammation; M. Baggiolini, M. Uguccioni, M. d'Apuzzo. 3. Induction of IL-1ra synthesis by hepatic acute phase proteins; J.W. Mier. 4. IL-6 signal transduction from the plasma membrane to the nucleus; F. Horn, C. Lutticken, U. Wegenka, J. Yuan, P.C. Heinrich. Section II: Signal Transduction Pathways and Effects. 5. Activation of NH-kappa-B and AP-1 in rat Kupffer cells; T.A. Tran-Thi, K. Decker, P.A.