This volume focuses on recent advances in understanding T cells as key players in antitumor immune responses, and as a result T cell-based immunotherapy is starting to transform the treatment of advanced cancers. However, despite recent successes, many patients with cancer fail to respond to these treatments. Defective migration of T cells into and within tumors is considered as an important resistance mechanism to cancer immunotherapy.
The volume includes three sections. The first section covers general knowledge about T cell trafficking during a normal immune response but also during tumor development. The second section provides an in-depth description of the different obstacles that prevent T cells from migrating and contacting tumor cells. The third section explores therapeutic strategies to improve trafficking of T cells into tumors and, thus, to enhance the effectiveness of cancer immunotherapy.
Contents
1 Basic rules of T cell migration
Jens V. Stein, Federica Moalli and Markus Ackerknecht
2 Regulation of anti-tumor T cell migration and function: contribution of real-time imaging
Pierre-Louis Loyher, Christophe Combadi?re and Alexandre Boissonnas
3 Vascular normalization, T cell trafficking and anti-tumor immunity
Kellsye L. Fabian and Walter J. Storkus
4 Disruption of anti-tumor T cell responses by cancer-associated fibroblasts
Arnaud Pommier and Douglas T. Fearon
5Cancer-associated Tertiary Lymphoid Structures, from basic knowledge toward therapeutic target in clinic
Bertrand Dubois, H?l?ne Kaplon, Coline Couillault, Christophe Caux, and Marie-Caroline Dieu-Nosjean
6Homing Improvement: Boosting T Cell Trafficking for Cancer Immunotherapy&lC=
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