Design and Analysis of Vaccine Studies [Paperback]

As well as being a reference for the design, analysis, and interpretation of vaccine studies, the text covers all design and analysis stages, from vaccine development to post-licensure surveillance, presenting likelihood, frequentists, and Bayesian approaches.

and Examples.- Overview of Vaccine Effects and Study Designs.- Immunology and Early Phase Trials.- Binomial and Stochastic Transmission Models.- and Deterministic Models.- Evaluating Protective Effects of Vaccination.- Modes of Action and Time-Varying VE.- Further Evaluation of Protective Effects.- Vaccine Effects on Post-Infection Outcomes.- Household-Based Studies.- Analysis of Households in Communities.- Analysis of Independent Households.- Assessing Indirect, Total, and Overall Effects.- Randomization and Baseline Transmission.- Surrogates of Protection.

From the reviews:

&The first comprehensive book on the topic of vaccine trials, their design and analysis. Given the recent interest in developing vaccines, &the book is timely, relevant and important. The authors are in the vanguard of the statistical and epidemiology aspects of vaccine research and development, and their combined expertise covers an impressively broad range of topics. &Useful for a diverse audience: graduate students, practicing biostatisticians, and professionals in epidemiology and infectious diseases. (Journal of Biopharmaceutical Statistics)

In their recent book & Halloran, Longini, Struchiner present many years of research on such studies much of which they have conducted. The book is aimed at three audiences: researchers specializing in vaccines and infectious diseases, those aiming to read their studies and students in related fields & . The book includes problems at the end of each chapter along with answers & . this is a well written and informative book. I recommend it to anyone interested in learning about vaccine studies. (Matthew C. Wiener, Technometrics, Vol.ló½