Dipeptidyl Aminopeptidases Basic Science and Clinical Applications [Paperback]

This is the first comprehensive volume on Dipeptidyl Aminopeptidases that can be marketed to a wide variety of disciplines, as well as to a variety of clinicians. Leading experts in the field contribute to this state-of-the-art view on these enzymes. This book comes at a time when our understanding of their function is growing ever more rapidly and therapeutic options have become imminent.

Dipeptidyl Aminopeptidases exert a potent modulatory role at an interface between immune mechanisms, metabolic responses, and neuroendocrine pathways. Experimental models and clinical studies addressing the role of these enzymes and the effect of specific inhibitors pave the way to novel therapeutic concepts in immunology, rheumatology, oncology, reproductive medicine and diabetes. Leading experts in the field will contribute to this book, which will present a state-of-the-art view on these enzymes at a time when our understanding of their function is growing ever more rapidly and therapeutic options have become imminent. The sections of the book will focus on various topics including DP IV and related enzymes in: expression and function, metabolic disorders, immune mechanisms and immune disorders, neuronal diseases and cancer, and related drug development.

Structure and Function.- Peptide Substrates of Dipeptidyl Peptidases.- Phosphorus-Containing Inhibitors of Proteolytic Enzymes.- Biochemical Properties of Recombinant Prolyl Dipeptidases DPP-IV and DPP8.- Prediction of Dipeptidyl Peptidase (DP) 8 Structure by Homology Modelling.- Dpiv-Related Enzymes.- Structure and Function in Dipeptidyl Peptidase IV and Related Proteins.- Expression and Function of Dipeptidyl Peptidase IV and Related Enzymes in Cancer.- DP8 and DP9 have Extra-Enzymatic Roles in Cell Adhesion, Migration and Apoptosis.- In Vivo Effects of a Potent, Selective Dppii Inhibitor.- Expression of Dipeptidyl Peptidase IV-Like Enzymes in Human Peripheral Blood Mononuclear Cells.- Diplƒg