Drug Metabolism and Pharmacokinetics Quick Guide [Paperback]

Drug Metabolism and Pharmacokinetics Quick Guide covers a number of aspects of drug assessment at drug discovery and development stages, topics such as?pharmacokinetics, absorption, metabolism, enzyme kinetics, drug transporters, drug interactions, drug-like properties, assays and in silico calculations. It?covers key concepts, with useful tables on physiological parameters (eg. blood flow to organs in x-species, expression and localization of enzymes and transporters), chemical structure, nomenclature, and moieties leading to bioactivation (with examples). Overall it?includes a number of key topics useful at the drug discovery stage, which would serve as a quick reference with several examples from the literature to illustrate the concept.

This Quick Guide covers aspects of drug assessment at the drug discovery and development stages, including pharmacokinetics, absorption, metabolism, enzyme kinetics, drug transporters, drug interactions, drug-like properties, assays and in silico calculations.Pharmacokinetics.- Drug Metabolizing Enzymes.- Oral Absorption.- Transporters.- Metabolism-Based Drug Interactions.- Biotransformation and Bioactivation.- Prediction of Human Pharmacokinetics.- Advances in Bioanalysis as it Relates to ADME.- ADME Properties and Their Dependence on Physicochemical Properties.- In Silico ADME Tools.- Approved Drugs.- Chemical Nomenclature.

From the reviews:

The authors have to be complimented with this comprehensive book of reference on various important topics in the field of pharmacokinetics and drug metabolism. It contains a large collection of figures and tables providing relevant and well-organized information. & In conclusion, this is a valuable reference for workers in the field of pharmacokinetics and drug metabolism, providing a storehouse of information in a comprehensive book. (Johannes H. Proost, International Journal of Clinical Pharmacology and Therapeuticsl“,