Dyneins Structure, Biology and Disease [Paperback]

Research on dyneins has a direct impact on human diseases, such as viruses and cancer. With an accompanying website showing over 100 streaming videos of cell dynamic behavior for best comprehension of material, Dynein: Structure, Biology and Disease is the only reference covering the structure, biology and application of dynein research to human disease. From bench to bedside, Dynein: Structure, Biology and Disease offers research on fundamental cellular processes to researchers and clinicians across developmental biology, cell biology, molecular biology, biophysics, biomedicine, genetics and medicine.

• Broad-based up-to-date resource for the dynein class of molecular motors
• Chapters written by world experts in their topics
• Numerous well-illustrated figures and tables included to complement the text, imparting comprehensive information on dynein composition, interactions, and other fundamental features

I History and Evolution

Chapter 1 Discovery of Dynein and its Properties : A Personal Account

Chapter 2 Evolutionary Biology of Dyneins

II Structure and Mechanics of Dynein Motors

Chapter 3 The AAA⁺ Powerhouse-Trying to Understand How it Works

Chapter 4 Dynein Motor Mechanisms

Chapter 5 Structural Analysis of Dynein Intermediate and Light Chains

Chapter 6 Biophysics of Dynein In Vivo

III Dyneins in Ciliary Biology

Chapter 7 Composition and Assembly of Axonemal Dyneins

Chapter 8 Organization of Dyneins in the Axoneme

Chapter 9 Genetic Approaches to Axonemal Dynein Function in Chlamydomonas and Other Organisms