ECTO-NOX Proteins Growth, Cancer, and Aging [Hardcover]

This volume?documents this unique family of cell surface proteins. Despite masquerading as intractable and difficult to clone and characterize, ENOX proteins have and continue to offer remarkable opportunities for research, commercial development and outside confirmation of therapeutic, diagnostic and new paradigms to help explain complex biological processes.This book covers ECTO-NOX, a family of cell surface-located proteins that exhibit cyanide-insensitive, timekeeping hydroquinone oxidase activity and a protein disulfide-thiol interchange activity that alternate with roles in growth, cancer and aging.

Preface.? ?Brief history of discovery and acknowledgments

1??The ECTO-NOX protein family

2??Measurement of ECTO-NOX (ENOX) activities

3??The constitutive ENOX1 (CNOX)

4??Role in plasma membrane electron transport

5??Role in the enlargement phase of cell growth

6??Role as ultradian oscillators of the cells biological clock

7??Other potential functional roles of ENOX proteins

8??ENOX2 (tNOX) and cancer

9??Age-related ENOX proteins (arNOX)

10??The auxin-stimulated ENOX and auxin-stimulation of plant growth

11??Cancer therapeutic applications of ENOX2 proteins

12??Diagnostic applicastions of ENOX2 proteins

Appendix A?Epilogue: Remaining challenges
Appendix B?Detailed description of 2-D gel electrophoresis western blot early detection protocol

ENOX Proteins documents a unique family of cell surface proteins which are the exclusive discovery (subsequently confirmed by others) of the authors, their students and their colleagues. An ENOX-based mechanism is provided for how cells increase in size that is both unique and applicable not only to cancer and cancer therapy but also to production agriculture anl³‡