Essentials of Apoptosis A Guide for Basic and Clinical Research [Paperback]

This is the second edition of the comprehensive, concise summary of apoptosis research. It covers the major concepts, molecular architecture, the biochemical pathways, and pathophysiological significance of apoptosis. This book provides a guideline of standard biochemical and cell biologic approaches to apoptosis bench work with an emphasis on translational clinical applications for immune disorders, cancer research, ischemia, and neuronal degeneration. Since the original publication in 2003, the apoptosis field has expanded rapidly  chapters not only need to be revised and expanded, but there is a need for all new chapters covering exciting advances in bioinformatics, systems biology, oxidative stress, etc.

This is the second edition of the comprehensive, concise summary of apoptosis research, a topic that has grown fast in recent years. It covers the major concepts, molecular architecture, biochemical pathways, and pathophysiological significance of apoptosis.

Essentials of Apoptosis (2nd edition)Table of ContentsPreface (2nd edition)Preface (1st edition)ContributorsPart I. Molecules and Pathways of ApoptosisChapter 1. Caspases: Activation, Regulation and FunctionStefan J. Riedl and Fiona L. ScottChapter 2. Bcl-2 Family ProteinsWenxing Ding and Xiao-Ming YinChapter 3. The Mammalian IAPs: Multi-faceted Inhibitors of ApoptosisEric C. LaCasse, Herman H. Cheung, Allison M. Hunter, Stephanie Plenchette, Douglas J. Mahoney and Robert G. KornelukChapter 4. Structure Biology of Programmed Cell DeathYigong ShiChapter 5. The Death Receptor PathwayMaria Eugenia Guicciardi and Gregory J. GoresChapter 6. The Mitochondrial Pathway: Focus on Shape ChangesSilvia Campello and Luca ScorranoChapter 7. The Endoplasm Reticulum PathwayMichael W. Harr and Clark W. DistelhorstChapter 8. Reactive Oxygen Species in Cell Fate DecisionsHan-Ming Shen and Shazib PervaizChapter 9. The Integration of Metabolism and Cell DeathJonathan L. Coloff, Yuxing Zhao anló²