Evolution-adjusted Tumor Pathophysiology The Novel Language of Tumor Biology [Hardcover]

Combined modularized therapies for metastatic cancer are pointing to central problems of communication among systems participators. A communication theory explains 'social engineering', endogenously induced or by implementing non-normative boundary conditions. Evolution-adjusted tumor pathophysiology is borne by an evolution theory, which contrasts narrative evolution histories. The tool of rationalizations constituting the tumor's normativity (inflammation, immune response etc.) represents the non-genomic counterpart of the tumor genome and should be additionally assessed during tumor staging. Evolution-adjusted tumor pathophysiology allows implementing applied systems biology, a novel clinical and pharmaceutical technology for bioengineering tumor response and personalizing tumor therapy. Combined modularized therapy, evolution-adjusted tumor pathophysiology, and universal biomarkers concertedly address genetically based tumor heterogeneity.

This volume presents evolution-adjusted tumor pathophysiology, which allows implementing applied systems biology, a novel clinical and pharmaceutical technology for bioengineering tumor response and personalizing tumor therapy.

Preface. I? Introduction.?1. Communication evolution pathophysiology: An endogenous conjunction Instead of an introduction. II? Combined modularized therapies for metastatic tumors: Pointing to central?problems of communication among systems participators in tumors.?2 Applied systems biology for the control of metastatic cancer: Therapeutic top-down strategy for targeting the tumors normativity. 3 Targeting the proangiogenic network in angiosarcomas: Biomodulatory therapy.4?Long-term results of combined modularized, immune-modulatory, angiostatic, and antiinflammatory therapy in systemically pre-treated multi-systems Langerhans cell histiocytosis. 5?Redirecting and modulating rationalizations of tumor-immanent normative functions in castration-resistant prostate anclÃ^