Glomerular filtration.- physiology and pathophysiology.- methods of investigation.- clearance of inulin.- clearance of endogenous creatinine.- plasma concentration of endogenous creatinine.- measurement of GFR by means of radionuclides.- non-routine methods of measurement of GFR under special conditions.- Urea.- physiology and pathophysiology.- methods of investigation.- plasma urea concentration and blood urea nitrogen (BUN).- the urea concentration in the urine.- urinary urea excretion.- renal urea clearance.- fractional urea excretion.- indications for investigation.- Renal plasma and blood flow.- physiology and pathophysiology.- methods of investigation.- measurement of CPah.- renal extraction of PAH.- calculation of the renal vascular resistance.- filtration fraction.- measurement of ERPF on the basis of radionuclides.- slope clearance of 131I-Hippuran.- the evaluation of separate ERPF.- indications for investigation.- Proteinuria.- physiology and pathophysiology.- classification of proteinuria.- methods of investigation.- bedside and laboratory screening methods for proteinuria.- the 24-hour protein excretion.- clearance of individual proteins and investigation of the selectivity of proteinuria.- polymer clearances.- indications for investigation.- Concentrating ability.- physiology and pathophysiology.- methods of investigation.- urinary osmolarity after 36 hr restriction of water intake.- urinary osmolarity after 24 hr restriction of water intake.- urinary osmolarity after 16 hr restriction of water intake.- scatter of Uosm and specific gravity values over 24 hr under conditions of free fluid intake.- urine osmolarity in the newly born and children.- urine osmolarity after VP or dDAVP administration.- tubular reabsorption of solute-free water.- indications for investigation.- Dilution of the urine.- physiology and pathophysiology.- methods of investigation.- simple (bolus) water load.- maintained maximal water diuresis.- induction of water diuresis by intrl“)