Experimental Metastasis Modeling and Analysis [Paperback]

Metastatic dissemination of cancer is a main cause of cancer related deaths, therefore biological mechanisms implicated in metastatic process presents an essential object of cancer research. This research requires creation and utilization of adequate laboratory models. The book describes main approaches to model processes of metastatic cancer dissemination and metastases development. The book is structured in according with various metastatic pathways reflecting molecular specificity of metastatic process as well as anatomical specificity of aria of dissemination. Each chapter is introduced by short discussion of clinical aspects of certain metastatic pathway. Especial attention is paid for methods of visualization, quantification and analysis of the modeled metastases. Additional chapter is devoted to methods of mathematic modeling of tumor spread. The data presented in the book may be helpful for cancer researchers and oncologists.

Preface. Chapter 1. Introduction. Chapter 2. Head and neck cancer. Chapter 3. Breast cancer invasion and metastasis. Chapter 4. Mouse models of pancreatic cancer. Chapter 5. ?Brain Metastasis. Chapter 6. ?Lung metastasis. Chapter 7. Liver Metastases. Chapter 8. Malignant pleural effusion. Chapter 10. Mathematic modeling of metastatic process. Index.

Metastatic dissemination remains a main cause for cancer related deaths. Investigation of the molecular mechanisms of the metastatic process presents an important area of cancer research and may provide clinical oncologists with new methods to prevent and manage cancer dissemination.

Availability of adequate experimental models is an essential requirement of the productive investigation. Over the many years of cancer research, plenty of model systems (in vitro and in vivo) were created to reproduce certain steps or to estimate certain aspects of metastatic process. CurrentlÃ%