Experimental Production of Diseases Heart and Circulation [Paperback]

Experimental Coronary Disease  Models and Methods of Drug Evaluation.- A. Introduction.- I. Definitions.- II. Common Role of Subendocardial Ischemia.- III. Objective of the Presentation.- B. Pathophysiology of Myocardial Ischemia.- I. Regulation of Tissue Oxygen Tension (pO2).- II. Autoregulation.- III. Effect of Antianginal Drugs.- C. Subendocardium and Effect of Drugs.- I. Anatomy of Circulation through Left Ventricular Wall.- II. Basal State of Left Ventricular Subepicardium and Subendocardium.- D. Regional Resistance  Large and Small Coronary Arteries.- I. Quantitative Angiography.- II. Large and Small Arteries in vivo.- III. Large and Small Arteries in vitro.- E. Regional Tissue Oxygen Tension.- I. Principle and Determinants of Oxygen Tension.- II. Approaches.- III. Polarographic Method.- IV. Mass Spectrographic Method.- V. Conclusions  Regional Oxygen Tension.- F. Regional Blood Flow and Perfusion.- I. Epicardium and Endocardium.- II. Microsphere Method.- III. Hydrogen Clearance with Electrodes.- IV. Mass Spectrometer.- V. Conclusions  Regional Flow.- G. Other Methods for Measurement of Coronary Blood Flow.- I. Thermodilution.- II. Heat Dissipation and Heat Production.- H. Blood Flow and Metabolism of Ischemic Region.- I. Retrograde Blood Flow (Back Flow).- II. Collateral Flow and Metabolism of Ischemic Region.- III. Collateral Flow in Unanesthetized Dogs.- I. Atherosclerosis Model.- Atrial Pacing.- J. Diffuse Coronary Occlusion  Small Vessels.- I. Ischemic Heart Failure and Cardiogenic Shock by Starch Suspensions, Lycopodium Spores or Small Microspheres.- II. Large Spheres  Intra-Aortic.- K. Acute Ligation.- I. Two-Stage Ligation in the Anesthetized Dog.- II. Two-Stage Ligation in the Anesthetized Pig.- III. Monkey, Unanesthetized.- L. Gradual or Controlled Occlusion.- I. Ameroids.- II. Dicetyl Phosphate.- III. Inflatable Balloon.- IV. Hydraulic Occluders.- V. Intracoronary Balloon.- M. Gradual or Acute Thrombosis.- I. Spiral Coils.- II. Electric Inductl£*