Extrasynaptic GABAA Receptors [Hardcover]

GABA is the principal inhibitory neurotransmitter in the CNS and acts via GABAA and GABAB receptors. Recently, a novel form of GABAA receptor-mediated inhibition, termed tonic inhibition, has been described. Whereas synaptic GABAA receptors underlie classical phasic GABAA receptor-mediated inhibition (inhibitory postsynaptic currents), tonic GABAA receptor-mediated inhibition results from the activation of extrasynaptic receptors by low concentrations of ambient GABA. Extrasynaptic GABAA receptors are composed of receptor subunits that convey biophysical properties ideally suited to the generation of persistent inhibition and are pharmacologically and functionally distinct from their synaptic counterparts. This book highlights ongoing work examining the properties of recombinant and native extrasynaptic GABAA receptors and their preferential targeting by endogenous and clinically relevant agents. In addition, it emphasizes the important role of extrasynaptic GABAA receptors in GABAergic inhibition throughout the CNS and identifies them as a major player in both physiological and pathophysiological processes.

1)?Chapter 1:? A brief introduction to extrasynaptic GABAA receptors and tonic GABAA receptor mediated inhibition in physiology and disease - Adam C Errington

2)?Extrasynaptic GABAA receptors: subunit composition, distribution, and regulation  Jean-Marc Fritschy and Patrizia Panzanelli

3)?Biophysical properties of recombinant y2 and d subunit containing GABAa receptors  Robert L MacDonald and Emmanueal J Botzolakis

4)?The pharmacology of extrasynaptic GABAa receptors  Keith A Wafford

5)?Neurosteroids and extrasynaptic GABAa receptors  William M Connelly

6)?Sources of GABA that activate extrasynaptic GABAa receptors  Damian Bright, Catriona Houston and Stephen Brickley

7)?Metabotropic receptor modulation of extrasynaptic GABAa receptors lÓ&