Fibrinolytics and Antifibrinolytics [Paperback]

With contributions by numerous expertsSect. I: Molecular Biology, Biochemistry, Physiology, and Pharmacology of the Plasminogen-Plasmin Enzyme System 1. The Fibrinolytic System and Thrombolytic Agents.- 2. Plasminogen and Streptokinase.- 3. Tissue-type Plasminogen Activator (tPA).- 4. Urinary-type Plasminogen Activator (uPA).- 5. The Inhibitors of the Fibrinolytic System.- 6. Assembly of the Plasminogen System on Cell Surfaces. Section II: Clinical Use of Thrombolytic Agents - In Acute Myocardial Infarction.- 7. Streptokinase and Anisoylated Lys-Plasminogen Streptokinase Activator Complex.- 8. Tissue-type Plasminogen Activator (tPA).- 9. Urokinase and Single-Chain Urokinase-Type Plasminogen Activator (Pro-urokinase).- 10. Comparative Evaluations of tPA vs SK with Particular Reference to the GUSTO-I Trial.- 11. Conjunctive Therapy to Reduce the Occurrance of Coronary Reocclusion after Thrombolytic Treatment of AMI.- - Thrombolytic Treatment of Other Clinical Thromboembolic Conditions.- 12. New Concepts in Thrombolysis of Pulmonary Embolism.- 13. Deep Venous Thrombosis. 14. Peripheral Arterial Occlusions.- 15. Thrombotic Cerebrovascular Disease.- - Thrombolytic Agents in Development, Biochemistry, Pharmacology, Efficacy in Animal Experiments and First Clinical Trials.- 16. Staphylokinase.- 17. Desmodus rotundus (Common Vampire Bat) Salivary Plasminogen Activator.- 18. Thrombus-Targeting of Plasinogen Activators. 19. The Hunt for the Ideal Thrombolytic Agent: Mutants of tPA and uPA, Chimera of both Molecules, Fibrolase.- 20. Agents which Increase Synthesis and Release of Tissue-Type Plasminogen Activator.- 21. Structure, Pharmacology and Clinical Use of Antifibrinolytic Agents.-The main benefit for the reader of this new edition of this topic in the Handbook of Experimental Pharmacology series is that it is a modern up-to-date presentation of the entire field of the treatment of arterial and venous thromboses with thrombolytic agents - the previous el3)