From Genome to Therapy Integrating New Technologies with Drug Development [Hardcover]

This important and exciting work brings together a high-calibre group of experts to discuss the practical application of genomic information to the development of drugs. Recent technological advances have led to a rapid acceleration in our ability to gather genetic data. The complete genetic sequences are now known for several organisms and accelerated programmes are in place for sequencing many other genomes, including human. The speed with which complete sequencing can be accomplished will continue to increase as new technologies come online. In principle, the scope for developing new diagnostic techniques and drugs is now greater than at any time in human history, but the pathway from genetic information to usable drug is a long and complex one.

This major book covers such subjects as the current state of the art in squencing technology, the applications of these new technologies to sequencing the genomes of various organisms, and the challenge of proteomics. Additional contributions deal with legal and ethical implications of the new uses of genetic data, and functional genomics from the point of view of the pharmaceutical industry.Introduction (J. Venter).

Electrophoresis-Based Fluorescent Dideoxy-Terminator Sequencing (J. Efcavitch).

Genomic Impact on Pharmaceutical Development (J. Venter).

From Transcription Regulation to Cell Cycle Checkpoint (R. Cai, et al.).

Mass Spectrometry Resurrects Protein-Approaches in Functional Genomics (M. Mann).

A Clinical Molecular Scanner to Study Human Proteome Complexity (D. Hochstrasser, et al.).

From Proteomics to Functional Analysis (J. van Oostrum, et al.).

Microbial Genome Sequencing: New Insights into Physiology and Evolution (C. Fraser).

Pharmacogenetics and Pharmacogenomics in the Discovery and Development of Medicines (A. Roses).&llã¯