Gastrointestinal Endocrinology [Paperback]

Leading clinical and basic science researchers present the latest molecular and cellular findings on key gut peptides, illuminating their physiology and pathophysiology, as well as highlighting the regulatory mechanisms underlying their action in the intestinal tract. The book focuses on gut peptide physiology and receptor pharmacology, gut processing and receptor biology, and on regulatory mechanisms in the gut, including pancreatic feedback mechanisms. Also included are chapters on the trophic effects of gut peptides on GI and pancreatic cancer; the regulation of gut peptide gene expression; and gastric secretion, especially in diseased states.Leading clinical and basic science researchers present the latest molecular and cellular findings on key gut peptides, illuminating their physiology and pathophysiology, as well as highlighting the regulatory mechanisms underlying their action in the intestinal tract. The book focuses on gut peptide physiology and receptor pharmacology, gut processing and receptor biology, and on regulatory mechanisms in the gut, including pancreatic feedback mechanisms. Also included are chapters on the trophic effects of gut peptides on GI and pancreatic cancer; the regulation of gut peptide gene expression; and gastric secretion, especially in diseased states.Introduction. Structure and Function of Gastrointestinal Endocrine Cells, Alison M. J. Buchan. Part I. Biochemistry, Pharmacology, and Receptor Biology. Biosynthesis and Processing of Gastrointestinal Peptide Hormones, Margery C. Beinfeld. Mechanisms that Attenuate Signaling by Regulatory Peptides, Stephan B?hm, Eileen F. Grady, and Nigel W. Bunnett. Cellular and Molecular Targets of Gastrin, Nadya Tarasova. Receptors for Peptides of the VIP/PACAP and PYY/NPY/PP Families, Marc Laburthe, Alain Couvineau, and Thierry Voisin. Part II. Regulatory Mechanisms and Systems. Physiology and Pathophysiology Cholecystokinin: Hormonal and Neurocrine Regulator of Postprandial Gastrointestinal FlÃq