Gene Action A Historical Account [Hardcover]

This is the only book written by someone working in the field that deals with the history of gene action. As a college student, Werner Maas took a course in genetics in 1941 and wondered why so little was said about the biochemical action of genes in controlling the specific function of an organism. Just at that time, biochemists and geneticists began to investigate jointly the basis of gene action, especially in microorganisms. Thus, Maas was able to witness firsthand the spectacular developments that led in the next twenty-five years to a clear picture of the action of genes. The history of these remarkable discoveries is the core of this book.
After 1965, building on insights gained from the work with microorganisms, studies of gene action turned to animals and plants and concentrated on processes not present in microorganisms, such as embryonic development, the role of genes in diseases, and the function of the nervous system. Because of the rapidity of technical advances made in handling genes, it has been possible to learn much about these complex processes. The last part of the book deals with these developments, which are ongoing parts of the history of gene action.

Preface
Part I: The Classical Period, 1860-1940
Prelude
1. Overture: The Garden of Mendel
2. Building a Scaffold: Genes Within Chromosomes
Part II: One Gene-One Enzyme, 1900-1953
Prelude
3. The Dawn of the One Gene-One Enzyme Hypothesis during the Classical Period
4. The Neurospora Era
5. E. coli Enters the Field
6. Biochemical Genetics in E. coli
7. The Chemical Nature of Genes
Part III: How Genes Determine Protein Structure
Prelude
8. Building a Theoretical Framework for Gene Action
9. Biochemical Identification of Adaptors
10. The Elusive Messenger
11. Deciphering the Code
Part IV: Regulation of Gene lc,