Gene Delivery and Therapy for Neurological Disorders [Hardcover]

This volume aims to explore the latest developments in adeno-associated viral and lentiviral vectors as well as the gene therapy strategies for?the most common neurological disorders, followed by chapters that include step-by-step guides to viral vector-based gene delivery in animal models used in the authors laboratories. Although safe gene manipulation in neural cells can be achieved, it may still be years away from efficacious gene-based treatment of neurological disorders such as Parkinson's and Alzheimers diseases due to the complexity of the underlying genetic/molecular mechanisms and the difficulty of developing reliable animal models. Gene Delivery and Therapy for Neurological Disorders seeks to aid researchers in this vital work.? Written in the popular Neuromethods series format, chapters include the kind of detailed description and expert implementation advice that leads to success in the lab.

Meticulous and authoritative, Gene Delivery and Therapy for Neurological Disorders serves as an ideal guide for researchers attempting to explore the potentials of gene therapy for neurological disorders.

1. Adeno-Associated Viral Vectors for Gene Delivery to the Nervous System

??????????? P?draig J. Mulcahy, Christopher Binny, Bartosz Muszynski, Evangelia Karyka, and Mimoun Azzouz

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2. Lentiviral Vectors for Gene Delivery to the Nervous System

??????????? Ioanna Eleftheriadou and Nicholas D. Mazarakis

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3. Gene Therapy for Parkinsons Disease: AAV-5-Mediated Delivery of Glial Cell Line-Derived Neurotrophic Factor (GDNF)

??????????? Bas Blits, Deniz Kirik, Harald Petry, and Stephen Hermening

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4. Gene Delivery and Gene Therapy for Alzheimers Disease

??????????? Maya Woodbury, TlÇ