Gene Therapy of Cancer [Hardcover]

The book provides a comprehensive overview of the current state, and the new concepts for the future directions of modern cancer therapy. Bringing together all the relevant aspects from basic and applied science, and the clinical experiences of this new direction in medicine, it is an up-to-date summary of the activities in the field and will be the basis for evaluating future progress in this area.Proceedings of the Third European Conference held in Berlin, Germany, September, 11-13, 1997Tumor Biology.- 1. Expression Genetics in Cancer Research, Prognosis, and Therapy.- 2. Patterns of Chromosomal Imbalances in Carcinomas of the Respiratory Tract.- 3. Inhibition of Tumorigenesis in a Murine B-Cell Lymphoma Transplant Model by c-Myc Complementary Oligonucleotides.- 4. Telomerase Inhibition by Induced Expression of Antisense RNA.- 5. Ex Vivo and in Vivo IGF-I Antisense RNA Strategies for Treatment of Cancer in Humans.- 6. Use of the IGF-I Antisense Strategy in the Treatment of the Hepatocarcinoma.- 7. Functional Involvement of CD44, a Family of Cell Adhesion Molecules, in Immune Responses, Tumour Progression and Haematopoiesis.- 8. The Influence of CD44 Splice Variants to the Outcome of Patients with Oral Squamous Cell Carcinoma.- 9. Control of Tumor Growth via Inhibition of Tumor Angiogenesis.- 10. Expression of Collagenase-3 (MMP-13) by Tumor Cells in Squamous Cell Carcinomas of the Head and Neck.- 11. High Level Expression of Tissue Inhibitors of Metalloproteinases-1,-2 and -3 in Melanoma Cells Achieved by Adenovirus Mediated Gene Transfer.- 12. Tissue Inhibitor of Metalloproteinase Expression: A Target for Gene Therapy in Renal Cell Carcinoma.- 13. In Vivo Tumor Suppressor Effect of Retrovirus-Mediated Gene Transfer of the Adenovirus E1a Gene.- 14. Antitumor Effect of E1B Defective Adenoviruses in Human Malignant Cells.- 15. Inhibition of Human Pancreatic Cancer Growth by the Adenovirus-Mediated Introduction of a Novel Growth Suppressing Gene, tob, in Vitro.ls&