Gene Therapy for Neurological Disorders and Brain Tumors [Hardcover]

Leading gene therapy researchers and clinicians illuminate the field-from basic vector technology to current and future clinical applications in neurology. The authoritative contributors provide cutting-edge reviews of the vectors available for gene transfer to the central nervous system, the strategies against CNS tumors, the potential strategies against neurologic disorder, and the limitations of today's gene therapy approaches. Also discussed are significant applications of gene therapy to brain tumors, Parkinson's disease, ischemia, and Huntington's chorea. Readers will learn the current delivery methods for transgenes, will learn the characteristics of transgene delivery vectors, and come to understand the therapy for both neuro-oncologic and neurologic disorders.

Leading gene therapy researchers and clinicians illuminate the field-from basic vector technology to current and future clinical applications in neurology. The authoritative contributors provide cutting-edge reviews of the vectors available for gene transfer to the central nervous system, the strategies against CNS tumors, the potential strategies against neurologic disorder, and the limitations of today's gene therapy approaches. Also discussed are significant applications of gene therapy to brain tumors, Parkinson's disease, ischemia, and Huntington's chorea. Readers will learn the current delivery methods for transgenes, will learn the characteristics of transgene delivery vectors, and come to understand the therapy for both neuro-oncologic and neurologic disorders.

Part i: Vectors and Promoters. Introduction, J. Glorioso. Retrovirus Vectors and Regulatable Promoters, S. Reeves. Adenovirus Vectors, M. Cotten. Herpes Simplex Virus: Recombinant Vectors, P. A. Johnson. Herpes Simplex Virus: Amplicon Vectors, C. Fraefel, X. O. Breakefield, and D. Jacoby. Adeno-Associated Virus Vectors, F. I. Smith and T. J. McCown. Epstein-Barr Virus Vectors, J.-M. H. Vos, K.lƒv