General Pharmacology [Paperback]

1: Methods of General Pharmacology.- General Considerations p. 4.  Selection of Material p. 5.  Employment of Physico-chemical Methods p. 5.  The Mathematical Interpretation of Biological Data p. 6.  Favourable Factors in Pharmacological Measurements p. 7.  Curves Relating Exposure to Drugs with Biological Effect p. 7.  Classes of Curves p. 8.  Discussion p. 9.- 2: The Cell as a Physico-chemical System.- The Structure of Protoplasm p. 10.  The Cell Surface p. 12.  Cell Permeability p. 12.  Structure of Plasmatic Membrane p. 14.  Cell Organisation p. 15.- 3: General Characteristics of the Cell-Drug System.- Dimensions of Molecules and Cells p. 17.  The Number of Molecules in Single Cells p. 19.  The Number of Enzyme Molecules per Cell p. 19.  Lethal Doses of Drugs per Cell p. 20.  Effective Doses of Drugs per Cell p. 21.  Minimum Active Doses of Drugs per Organism p. 22.  Minimum Active Dilutions of Drugs p. 22.  Intracellular Administration of Drugs p. 23.  Types of Action of Drugs on Cells p. 25.  Discussion p. 25.- 4: Reactions between Drugs and Active Proteins.- Symplex Compounds p. 26.  Combination of Haemoglobin with Oxygen and Carbon Monoxide p. 27.  Antagonism of Oxygen and Carbon Monoxide p. 29.  Discussion p. 30.- 5: The Action of Drugs on Catalysts and Enzymes.- Poisoning of Inorganic Catalysts p. 31.  General Characters of Enzymes p. 33.  Enzyme Activity p. 34.  General Characters of the Poisoning of Enzymes p. 34.  Diphasic Actions of Enzyme Poisons p. 36.  The Rate of Action of Enzyme Poisons p. 37.  Relation between Concentration of Poison and Inhibitien of Enzyme p. 37.  Discussion p. 40.- 6: Action of Heavy Metals on Enzymes in vitro and in vivo.- Action of Heavy Metals on Saccharase p. 40.  Concentration-action Relations of Heavy Metals and Enzymes p. 42.  The Action of Metals on Living Cells p. 44.  Relation between Metal Concentration and Action on Cells p. 44.  Minimum Lethal Concentrations of Heavy Metals p. 44.l“0