General Pharmacology [Paperback]

1: Methods of General Pharmacology.- General Considerations.- Selection of Material.- Employment of Physicochemical Methods.- The Mathematical Interpretation of Biological Data.- Favourable Factors in Pharmacological Measurements.- Curves Relating Exposure to Drugs with Biological Effect.- Classes of Curves.- Discussion.- 2: The Cell as a Physicochemical System.- The Structure of Protoplasm.- The Cell Surface.- Cell Permeability.- Structure of Plasmatic Membrane.- Cell Organisation.- 3: General Characteristics of the Cell-Drug System.- Dimensions of Molecules and Cells.- The Number of Molecules in Single Cells.- The Number of Enzyme Molecules per Cell.- Lethal Doses of Drugs per Cell.- Effective Doses of Drugs per Cell.- Minimum Active Doses of Drugs per Organism.- Minimum Active Dilutions of Drugs.- Intracellular Administration of Drugs.- Types of Action of Drugs on Cells.- Discussion.- 4: Reactions between Drugs and Active Proteins.- Symplex Compounds.- Combination of Haemoglobin with Oxygen and Carbon Monoxide.- Antagonism of Oxygen and Carbon Monoxide.- Discussion.- 5: The Action of Drugs on Catalysts and Enzymes.- Poisoning of Inorganic Catalysts.- General Characters of Enzymes.- Enzyme Activity.- General Characters of the Poisoning of Enzymes.- Diphasic Actions of Enzyme Poisons.- The Rate of Action of Enzyme Poisons.- Relation between Concentration of Poison and Inhibition of Enzyme.- Discussion.- 6: Action of Heavy Metals on Enzymes in vitro and in vivo.- Action of Heavy Metals on Saccharase.- Concentration-action Relations of Heavy Metals and Enzymes.- The Action of Metals on Living Cells.- Relation between Metal Concentration and Action on Cells.- Minimum Lethal Concentrations of Heavy Metals.- Relative Toxicity of Metals.- Course of Reaction between Metals and Cells.- Diphasic Actions of Metals on Cells.- Discussion.- 7: Action of Various Enzyme Poisons in vitro and in vivo.- The Action of Dyes on Enzymes.- Action of Quinine on Enzymes.- Action of Quininel3³