Genes and Cardiovascular Function [Hardcover]

Rapid advances in molecular medicine have led to pronounced new developments in experimental and clinical cardiology.? In the embrace of modern molecular biology and bridging the gap between the clinical and the genomic, cardiovascular medicine has seen major strides in the understanding of the molecular mechanisms that drive disease progression.? The ability to rapidly identify candidate human genes for cardiovascular diseases lends itself to the development of diverse strategies for disease treatment and management.? The wide variety of gene expressions proffers excellent targets for novel therapeutics.? Gene therapy is steadily increasing in viability and represents a fascinating arena of research and clinical focus.

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This book is based on two international Mendel symposia on Genes and the Heart, joint meetings of the Japanese and European sections of the International Academy of Cardiovascular Sciences.? Highlighting selected symposia contributions, this book explores the role of molecular biology and genetics in the basic knowledge, genesis, and clinical interventions of cardiovascular diseases.

Reflecting the collaborative work of international authorities, this book offers an in-depth discussion of the experimental basis of the practice of cardiology. It focuses on how the manipulation of therapeutics can be used to exploit specific targets.

A. Genes and the Heart

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1.? Johann Gregor Mendel Father of modern genetics

???? P. Braveny

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2.? Gene therapy: hopes and problems

???? V. Vonka

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B. Development and Gender

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3.? VEGFs, FGFs and PDGF coordinate embryonic coronary vascularization

???? R.J. Tomanek, L.P. Christenló*