Genes and Environment in Cancer [Paperback]

Different cancer types can result from a multiplicity of genetic and environmental factors. In recent years a number of genes have been identified as strong determinants for particular forms of cancer (particularly colon and breast cancer). The incomplete penetrance often evinced by the mutations of these genes has raised the possibility that additional endogenous or exogenous determinants contribute to cancer development or suppression. The major aim of this book is to present an integrated view of the various environmental, epidemiological and genetic determinants that contribute to a disease syndrome collectively known as cancer .Different cancer types can result from a multiplicity of genetic and environmental factors. In recent years a number of genes have been identified as strong determinants for particular forms of cancer (particularly colon and breast cancer). The incomplete penetrance often evinced by the mutations of these genes has raised the possibility that additional endogenous or exogenous determinants contribute to cancer development or suppression. The major aim of this book is to present an integrated view of the various environmental, epidemiological and genetic determinants that contribute to a disease syndrome collectively known as cancer .Key Notes.- Epidemiological Evidence of the Effects of Behaviour and the Environment on the Risk of Human Cancer. Molecular Epidemiology of Human Cancer. Risk Assessment and DNA Lesions.- Molecular Epidemiology of Environmental Carcinogenesis. Polymorphisms of N-Acetyltransferases, Glutathione S-Transferases, Microsomal Epoxide Hydrolase and Sulfotransferases: Influence on Cancer Susceptibility. Impact of Adduct Determination on the Assessment of Cancer Susceptibility. Mutation Spectra Resulting from Carcinogenic Exposure: From Model Systems to Cancer-Related Genes. DNA Repair and Genetic Susceptibility.- Relevance of DNA Repair to Carcinogenesis and Cancer Therapy. Molecular Basis of DNA Repair Mechanisms ls•