The Genetics and Development of Scoliosis [Paperback]

Developmental genetic studies of the spine and linkage and family-based association studies have led to recent advances in understanding the genetic etiology of idiopathic, neuromuscular, and congenital forms of scoliosis. The book is written by leaders in genetic and developmental research on scoliosis and developmental studies of the spine.

Recent genetic studies of the spine has enhanced the understanding the genetic etiology of idiopathic, neuromuscular, and congenital forms of scoliosis. These findings are discussed in this timely review of scoliosis and developmental studies of the spine.

Scoliosis is a heterogeneous group of spinal curvature disorders that are frequently encountered by health professionals (estimated to affect 2-3% of the population). Patients are concerned about prognosis, associated health conditions and recurrent risks. Developmental genetic studies of the spine and linkage and family-based association studies have led to recent advances in understanding the genetic etiology of idiopathic, neuromuscular, and congenital forms of scoliosis. The book is written by leaders in genetic and developmental research on scoliosis and developmental studies of the spine. Recent developments in clinical and molecular genetic studies of these disorders are also discussed.Genetic Regulation of Somite and Early Spinal Patterning.- Development and Functional Anatomy of the Spine.- Environmental Factors and Axial Skeletal Dysmorphogenesis.- Overview and Comparison of Idiopathic, Neuromuscular, and Congenital Forms of Scoliosis.- Abnormal Vertebral Segmentation (or Segmentation Defects of the Vertebrae) and the Spondylocostal Dysostoses.- Spondylothoracic Dysostosis in Puerto Rico.- Progress in Understanding Genetic Contributions in Syndromic and Non-Syndromic Disorders Associated with Congenital, Neuromuscular, and Idiopathic Scoliosis.- Genetics and Functional Pathology of Idiopathic Scoliosis.- Current Understanding of Genetic Factors in IlÃ`