Genetics and Genomics for the Cardiologist [Paperback]

Genetics and Genomics for the Cardiologist is a concise, but comprehensive volume for the clinical cardiologist or medical student interested in learning how molecular genetics is now being applied to prevention and treatment of heart diseases, from DNA tests to pharmacogenomics and gene-based therapeutics. The volume, written in a plain language, contains detailed figures. A rich glossary, three appendices, many references and several URLs provide additional sources of information.Genetics and Genomics for the Cardiologist is a concise, but comprehensive volume for the clinical cardiologist or medical student interested in learning how molecular genetics is now being applied to prevention and treatment of heart diseases, from DNA tests to pharmacogenomics and gene-based therapeutics. The volume, written in a plain language, contains detailed figures. A rich glossary, three appendices, many references and several URLs provide additional sources of information.Preface. Acknowledgements.1: The Human Genome. 1.1. Size and characteristics of nuclear and mitochondrial genome in humans. 1.2. Structural and functional organization of human chromosomes. 1.3. Structural and functional organization of human genes. 1.4. Artificial banding of human chromosomes. 1.5. Replication of human DNA and the origin of new mutations. 1.6. Effects of mutations in DNA sequences. 1.7. DNA markers. 1.8. Chromosomal basis of inheritance. 1.9. The main reference database for human disease genes. 1.10. The Human Mutation Database and the nomenclature for human mutations.2: From Genome to Clinical Genotype. 2.1. Analyzing the human transcriptome. 2.2. The differential expression of human genes. 2.3. From transcriptome to proteome and metabolome. 2.4. The transcriptome of the human heart. 2.5. Genotype and phenotype. 2.6. Molecular explanation of dominance of some mutations. 2.7 Gene dosage. 2.8. Peculiarity of phenotypes due to mutations ilÃ)