The contributed volume collects cutting-edge research in GeoComputational Analysis of Regional Systems. The contributions emphasize methodological innovations or substantive breakthroughs on many facets of the socio-economic and environmental reality of regional contexts.Introduction: Progress in GeoComputational Research.- Code as Text: Open Source Lessons for Geospatial Research and Education.- Considering diversity in spatial decision making.- Cyberinfrastructure-enabled High-performance and Parallel Computing for Geocomputational Modeling.- Agent-Based Modeling of Climate Change, Land Acquisition and Household Dynamics in Southern Ethiopia.- Modelling Regional Urban Dynamics: the JingJinJi Metropolitical Area in China.- Simulation of land use change and building construction for construction of new road infrastructure.- A Cellular Automata Model to Study Classical Technical Change at Municipalities in Mexico 1999-2009.- Multi-Agent-based Simulation on the Evolution and Development of Chinese Regional Economy with Technology and Capital Diffusion.- Integrating GIS and ABM to Explore Spatio-temporal Dynamics of Slum Formation in Ahmedabad, India.- The Spread of Cholera in Dadaab Refugee Camps: An Agent Based Modeling Perspective.- Labor mobility and Creative Class across Metropolitan Areas of Mexico: an agent based modeling approach.- Mapping Brazilian Economic and Social Scenario Using GIS, Multivariate Statistics and Neural Networks.- Machine Learning and landslide assessment in a GIS environment.- Influence of DEM Uncertainty on the Individual-based Modeling of Dispersal Behavior: A Simple Experiment.- A Microsimulation Model of Labor Force Updating for the Integrated Land Use, Transportation, Environment (ILUTE) Model System.- Can remotely sensed data capture socio-economic spatial patterns?.- Integration of soft computing with GIS for modeling land-use suitability.- A Semi-Automated Software Framework for Delineating Oil And Well Pad Footprints In Alberta, CalÓ)