Glucocorticoids [Paperback]

Following 50 years of glucocorticoid use in a clinical setting, aninternational body of expert scientists and physicians presents the mostexpansive survey of glucocorticoid pharmacology to date. This worktraces the history of glucocorticoid biology from the seminaldescription of glucocorticoid insufficiency by Thomas Addison in themid-19th century, up to current advances in elucidating the molecularbasis of glucocorticoid action. Important discoveries are presented, aswell as milestones in drug development, a survey of current clinicalpractice, and prospects for novel glucocorticoid-based therapeutics.Scientists and clinicians will appreciate the scope of this work, whichis of special interest to workers in the fields of endocrinology,inflammation and autoimmune disease.Following 50 years of glucocorticoid use in a clinical setting, aninternational body of expert scientists and physicians presents the mostexpansive survey of glucocorticoid pharmacology to date. This worktraces the history of glucocorticoid biology from the seminaldescription of glucocorticoid insufficiency by Thomas Addison in themid-19th century, up to current advances in elucidating the molecularbasis of glucocorticoid action. Important discoveries are presented, aswell as milestones in drug development, a survey of current clinicalpractice, and prospects for novel glucocorticoid-based therapeutics.Scientists and clinicians will appreciate the scope of this work, whichis of special interest to workers in the fields of endocrinology,inflammation and autoimmune disease.The development of glucocorticoids as therapeutic agents.- Glucocorticoid biology  a molecular maze and clinical challenge..- Glucocorticoid biology  a historical perspective.- The development of synthetic glucocorticoids.- Molecular mechanisms of glucocorticoid action.- The glucocorticoid receptor: expression, function, and regulation of glucocorticoid responsiveness.- Molecular and cellular aspects of cytokine regulation by glucocl£Y