Glutamate and Addiction [Paperback]

In Glutamate and Addiction, world-renowned scientific experts critically review all of the evidence for the role of glutamatergic systems in opiate, stimulant, and alcohol addiction. Using a variety of pharmacological, biochemical, genetic, and brain imaging techniques, these investigators show precisely how glutamate affects such addictions and how modifying certain elements of the glutamatergic system appear to alleviate particular components of addiction. Their survey takes in both clinical approaches using medications that influence glutamate and cutting-edge preclinical approaches that manipulate specific subtypes of glutamate receptors or specific substrates of the glutamate cascade to determine their roles in various addictive states.In Glutamate and Addiction, world-renowned scientific experts critically review all of the evidence for the role of glutamatergic systems in opiate, stimulant, and alcohol addiction. Using a variety of pharmacological, biochemical, genetic, and brain imaging techniques, these investigators show precisely how glutamate affects such addictions and how modifying certain elements of the glutamatergic system appear to alleviate particular components of addiction. Their survey takes in both clinical approaches using medications that influence glutamate and cutting-edge preclinical approaches that manipulate specific subtypes of glutamate receptors or specific substrates of the glutamate cascade to determine their roles in various addictive states.I. Introduction: Physiology and Pharmacology of GlutamatePhilip H. Sheridan, Forrest F. Weight, and Barbara H. Herman, Section EditorsMolecular Pharmacology and Physiology of Glutamate ReceptorsKarin Borges and Raymond DingledinePharmacology of Glutamate ReceptorsJeffrey M. Witkin, Rafal Kaminski, and Michael A. RogawskiGlutamate and NeurotoxicityB. Joy Snider and Dennis W. ChoiMaturational Regulation of Glutamate Receptors and Their Role in NeuroplasticityRussell M. Sanchez and Frances E.lS$