The Golgi Apparatus State of the art 110 years after Camillo Golgi's discovery [Hardcover]

This book summarizes all new data obtained after development of methods of Golgi complex sub fractionation, molecular biology and microscopy. It collects the full range of expertise, different points of view and different approaches. The book is devoted to molecular modes of the function of the Golgi apparatus as a whole, taking into account all experimental data. The book aims to make the functional organization of the Golgi apparatus more understandable.

General considerationsThe Golgi apparatus and main discoveries in the field of intracellular transportThe Golgi apparatus as a crossroads in intracellular trafficMain machineries operating at the Golgi apparatusSNAREsRabsCOPIICOPI: mechanisms and transport rolesArfs and Arls: models for Arf family members in membrane traffic at the GolgiCOG complexThe TRAPP complexThe role of Ca2+ in the regulation of intracellular transportGolgi glycosylation enzymesNucleotide sugar transporters of the Golgi apparatusLuminal lectinsThe Golgi ribbon and the function of the golginsFunctional cross talk between membrane trafficking and cell signallingThe role of the cytoskeleton in the structure and function of the Golgi apparatusThe dynamincortactin complex as a mediator of vesicle formation at the trans-Golgi networkThe geometry of organelles of the secretory pathwayMain transport stepsER-to-Golgi transportIntra-Golgi transportStructure and domain organization of the trans-Golgi networkGolgi-to-PM transportProtein transport from the trans-Golgi network to endosomesThe transport of soluble lysosomal hydrolases from the Golgi complex to lysosomesTransport of lysosomal membrane proteins from the Golgi complex to lysosomesRetrograde endosome-to-TGN transportRetrograde plasma membrane-to-Golgi apparatus transportInteractions between endocytosis and secretory transportOrigins of the regulated secretory pathwaySecretion and endocytosis in endothelial cellsFormation of mucin granulesGolgi apparatus and epithelial cell plI