Handbook of Neurobehavioral Genetics and Phenotyping [Hardcover]

The Handbook of Behavioral Genetics and Phenotyping represents an integrative approach to neurobehavioural genetics; worldwide experts in their field will review all chapters. Advanced overviews of neurobehavioural characteristics will add immense value to the investigation of animal mutants and provide unique information about the genetics and behavioural understanding of animal models, under both normal and pathological conditions. Cross-species comparisons of neurobehavioural phenotypes will pave the way for an evolutionary understanding of behaviour.

Moreover, while biological sciences are progressing towards a holistic approach to investigate the complexity of organisms (i.e., “systems biology” approach), an integrated analysis of behavioural phenotyping is still lacking. The Handbook of Behavioral Genetics and Phenotyping strengthens the cross-talk within disciplines that investigate the fundamental basis of behaviour and genetics. This will be the first volume in which traditionally distant fields including genomics, behaviour, electrophysiology, neuroeconomics, and computational neuroscience, among others, are evaluated together and simultaneously accounted for during discussions of future perspectives.

List of Contributors xix

Preface xxv

1 Genetic Screens in Neurodegeneration 1
Abraham Acevedo Arozena and Silvia Corrochano

Introduction 1

The Genetics of Neurodegenerative Disorders 2

Neurodegeneration Disease Models 4

Genetic Approaches to Discover New Genes Related to Neurodegeneration Using Disease Models 5

Saccharomyces cerevisiae 6

Caenorhabditis elegans 8

Drosophila melanogaster 9