Heat Shock Proteins and Cytoprotection Atp-Deprived Mammalian Cells [Hardcover]

1. Heat Shock Proteins and the Regulation of Heat Shock Gene Expression in Eukaryotes.- 1.1. The Family of Stress Proteins and Molecular Chaperones.- 1.2. The Regulation of Heat Shock Gene Expression in Eukaryotes.- Concluding Remarks.- 2. ATP Homeostasis, Ionic Balance and Cell Viability.- 2.1. ATP Homeostasis in Mammalian Cells.- 2.2. Cell Viability and ATP Depletion.- 2.3. Significance of Ionic Imbalance for the Death of ATP-Depleted Cells.- 2.4. Mitochondrial Dysfunction and Damage During Ischemia.- Concluding Remarks.- 3. Proteotoxicity of ATP Depletion: Disruption of the Cytoskeleton, Protein Aggregation and Involvement of Molecular Chaperones.- 3.1. The Cytoskeleton Under ATP Deprivation.- 3.2. Protein Aggregation in Energy-Deprived Cells.- 3.3. How Do Heat Shock Proteins Respond to ATP Depletion?.- Concluding Remarks.- 4. ATP Depletion as Inducer of Heat Shock Protein Expression.- 4.1. Anoxia and Mitochondrial Inhibitors Activate HSP Gene Expression.- 4.2. Ischemia-Induced HSP Synthesis in the Heart.- 4.3. Stress Protein Expression in Post-Ischemic Brain.- 4.4. Ischemia-Induced Stress Protein Synthesis in Other Normal Tissues and Tumor Cells.- 4.5. Possible Mechanisms of HSP Accumulation After ATP Depletion.- Concluding Remarks.- 5. Heat Shock Proteins and Cardioresistance to Ischemia.- 5.1. Heat Shock-Induced Cardioresistance to Ischemia/Reperfusion Injury.- 5.2. The Role of Myocardial HSPs in Ischemie Preconditioning.- 5.3. The Cardioresistance Induced by Other Stimuli Can Also Be Associated with HSPs.- 5.4. Evidence for the Involvement of HSP70 in Cardioprotection.- 5.5. Are Other Stress Proteins Cardioprotective?.- Concluding Remarks.- 6. Involvement of Heat Shock Proteins in Protection of Various Normal and Tumor Cells from Ischemic Insult.- 6.1. HSPs and Ischemic Tolerance in the Brain.- 6.2. Ischemic Tolerance in the Kidney.- 6.3. HSPs and Protection from Ischemia of Other Organs and Tissues.- 6.4..- Concluding Remarks.- 7. What Are the Mechanisms ol³%