Hormonally Active Brain Peptides Structure and Function [Paperback]

1 Structure and Function Relationships among Synthetic Enkephalin Analogues.- 1. Introduction.- 2. Opiate Activity of Enkephalins and ?-Endorphin.- 3. Design and Synthesis of Enkephalin Analogues with Improved Opioid Activity.- 4. Modification at the N Terminus.- 5. Modification at the C Terminus.- 6. Conclusions.- Discussion.- References.- 2 Secondary Structure  Function Relationships in ?-Endorphin: A Proposed Model of the Biologically Active Conformation.- 1. Introduction.- 2. Circular Dichroism Studies.- 3. Predictive Analysis of the Secondary Structure.- 4. Correlation between the Solution Conformation and Biological Activity.- References.- 3 Studies on the Conformation of Neuropeptides.- 1. Introduction.- 2. Material and Methods.- 3. ACTH.- 4. Angiotensin II.- 5. Thyroliberin.- 6. Conclusion.- Discussion.- References.- 4 The Search for the Active Center of the Gonadotropins.- 1. Introduction.- 2. Methods in Peptide Synthesis.- 3. Testing of Inhibitory Peptides.- 4. Discussion.- 5. Summary.- 6. Projections for the Future.- Discussion.- References.- 5 Hormonal Antagonistic Properties of Deglycosylated Pituitary Lutropin.- 1. Introduction.- 2. Preparation of Deglycosylated LH.- 3. Biological Properties of DG-LH.- 4. Concluding Comments.- References.- 6 Hormonal Regulation of and Ionic Requirements for in Vitro Release of Hypothalamic Peptides.- 1. Introduction.- 2. Effects of Neurotransmitters or Neuropeptides on Hypothalamic Hormone Release in Vitro.- 3. Interaction of Opiates with LH-RH and SRIF Release.- 4. Ionic Requirements of Neuropeptide Release.- 5. Are Neuropeptide-Neurotransmitter Interactions Coupled with Ionic Channels?.- 6. Hormonal Effect on Neuropeptide Release in Vitro.- 7. Conclusion.- References.- 7 In Vitro Release of Luteinizing Hormone-Releasing Hormone: Influence of Estrogen and a Mammary Carcinogen.- 1. Introduction.- 2. Methods.- 3. Results.- 4. Discussion.- Discussion.- References.- 8 Mode of Opioid and Catecholamine Involvement in Regull£6