The Human Adrenal Cortex Pathology and Biology An Integrated Approach [Paperback]

1. Introduction.- 2. Historical Aspects.- A. The Normal Adrenal Cortex.- 3. Origin and Development of the Adrenal Gland.- Embryology.- Fetal Development.- Postnatal Development.- 4. Structure of the Adult Adrenal Cortex.- Gross Anatomy.- Weight.- Blood Supply.- Light-Microscopic and Ultrastructural Appearance.- The Normal Gland.- The Effects of Adrenocorticotrophic Hormone (ACTH).- Intraglandular Vascularisation.- Lymphatic Supply.- Innervation.- 5. The Effect of Stress on the Structure of the Adrenal Cortex.- 6. Morphological Changes in the Adrenal Cortex with Age.- The Prenatal Cortex.- The Neonatal and Prepubertal Cortex.- The Postpubertal Cortex.- Adrenocortical Nodules.- The Autopsy Black Nodule.- 7. Iatrogenic Changes.- ACTH.- Steroid Therapy.- Inhibitors of Adrenal Steroidogenesis.- Aminoglutethimide.- Spironolactone.- O,p-DDD (Mitotane, Lysodren).- Other Inhibitors.- 8. Functional Activity of the Adrenal Cortex.- Adrenal Chemistry.- Steroids.- Lipids.- Vitamins.- Hormonogenesis by the Adult Adrenal Cortex.- Pathways of Steroidogenesis.- Molecular Mechanisms of Steroidogenesis.- Inhibitors of Steroidogenesis.- Control of Adult Steroidogenesis.- Glucocorticoids.- Mineralocorticoids.- Sex Steroids.- Hormonogenesis by the Prepubertal and Pubertal Cortex.- Hormonogenesis by the Prenatal Adrenal Cortex.- Pathways of Steroidogenesis.- The Feto-placental Unit.- Functions of Fetal Adrenal Steroids.- Control of Prenatal Hormonogenesis.- 9. Regulation of Growth of the Adrenal Cortex.- The Prenatal Gland.- Growth.- Involution.- The Postnatal Gland.- Adult Tissue Homeostasis and Regenerative Growth.- 10. Functional Zonation of the Adrenal Cortex.- Zonal Functions of the Cortex.- Mechanisms of Functional Zonation.- B. Hypercorticalism.- 11. General Incidence and Pathological Changes.- Factors Predisposing to Hypercorticalism.- 12. Cushings Syndrome.- Bilateral Adrenocortical Hyperplasia.- Simple (or Diffuse) Hyperplasia.- Bilateral Nodular Hyperplasia.- Hyperplasia anl£