Human Papillomaviruses and Cervical Cancer Biology and Immunology [Hardcover]

Cervical cancer is a major disease worldwide, with 500,000 new cases diagnosed every year. Through etiological studies, an association has been established with HPV infection throughout the pathological spectrum of this disease. A timely review of HPV infection in cervical cancer, this book provides the background to the potential for immunological intervention. Basic background is provided, ensuring the book's accessibility to all. Each chapter is integrated so that the book as a whole provides a detailed insight into the most relevant scientific issues of HPV and cervical cancer. This book will provide an interface for students, scientists and clinicians with a realistic and critical evaluation of the advances and problems in the implementation of immunologically based prophylactic and therapeutic strategies in HPV-associated disease.

1. The pathology of cervical intro-epithelial neoplasia carcinoma and human papilloma-virus infection
2. Molecular genetics of human papilloma viruses
3. Detection of human papilloma virus infections
4. Epidemiology of HPV and cervical cancer
5. Mechanisms of transformation by HPV
6. Virus keratinocyte interactions in the infectious cycle
7. Serological immune response to HPV
8. the search for cell-mediated immunity to HPV: prospects for vaccine design
9. MHC expression in the natural history of cervical cancer
10. Towards vaccines against papilloma virus
11. Immunological aspects of cutaneous warts
12. Concluding remarks