Hypertension and the Brain as an End-Organ Target [Hardcover]

The first comprehensive overview of the effects of?hypertension on the brain. The book discusses not only the relationship between?hypertension and stroke, but also the much less studied relationship?between hypertension and cognitive decline and neurodegenerative?diseases such as Alzheimer's. It seeks to answer two important questions. First, what are the conditions under which hypertension is associated with stroke, cognitive?decline, and neurodegenerative disease? And second, what are the?biological mechanisms by which hypertension alters brain homeostasis? By looking at the biological mechanisms of?these relationships, this book provides insight to neuroscientists and?neurologists regarding why anti-hypertension treatments make a big?difference in the case of stroke, but have very little impact on cognitive?decline and brain aging.

A systematic review of reviews to examine the association between hypertension and cognitive impairments in adults.- Hypertension and age-related cognitive decline.- Hypertension and stroke.- Neuroimaging as a research tool in human essential hypertension.- Cognitive Dysfunction and Dementia in animal models of hypertension.- The effects of hypertension on cerebral artery structure and function, and cerebral blood flow.- Arterial stiffness and the brain.- Endothelium, the blood-brain barrier, and hypertension.- Hypertension and brain inflammation: role of RAS-induced glial activation.- Sex differences in neural regulation of hypertension.

Dr Girouard completed her PhD in cardiovascular physiology in 2002 at the Universit? de Montreal under the supervision of Dr. J. de Champlain, a specialist in the field of hypertension. She then pursued two fellowships,?both on the study of cerebrovascular regulation: one at the Weill Medical College of Cornell University and a second at the University of Vermont under the supervisions of Dr. Costantino Iadecola and Dr Mark T. Nelson, respectively. She is l+