Imaging Mass Spectrometry Methods and Protocols [Hardcover]

This volume addresses the various techniques and novel applications of mass spectrometry imaging (MSI) and its role as a discovery tool in the field of proteomics, lipidomics, and metabolomics. The chapters in this book demonstrate how MSI can be applied to many areas of research such as clinical pathology, translational medicine, toxicology, biomarkers and response studies, and potential incorporation of MSI into forensic workflows. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Innovative and comprehensive, Imaging Mass Spectrometry: Methods and Protocols is a valuable resource for research scientists and clinicians who are interested in further studies of MSI technologies.

Preface&
Table of Contents&
Contributing Authors&

1. A Future Amalgamation between the Scientist and the Clinician?
Sarah Haywood-Small

2. Fresh Frozen Versus Formalin Fixed Paraffin Embedded for Mass Spectrometry Imaging
Ekta Patel

3. Imaging MS of Rodent Ocular Tissues and the Optic Nerve
David M.G. Anderson, Wendi Lambert, David J. Calkins, Szolt Abloczy, Rosalie K. Crouch, Richard M. Caprioli, and Kevin L. Schey

4. MALDI-MSI of Lipids in Human Skin
Philippa J. Hart and Malcolm R. Clench

 

5. MALDI-MSI Analysis of Cytological Smears: The Study of Thyroid Cancerló,