Immune Mechanisms in Renal Disease [Paperback]

1 Functional Organization of the Glomerulus: Presence of Glycosaminoglycans (Proteoglycans) in the Glomerular Basement Membrane.- 1. Introduction.- 2. Glomerular Capillary Organization Is Highly Specialized.- 3. Epithelial Polyanion Functions to Maintain Normal Foot Processes and Filtration Slits.- 4. Epithelial Slits Effectively Ruled Out as the Main Filtration Barrier.- 5. The GBM Is Both the Size-Selective and the Charge-Selective Barrier in the Glomerulus.- 6. Distinction between Anionic Sites in the GBM and Those on Cell Surfaces.- 7. Anionic Sites Are Lost from the GBM as Well as the Epithelium in Aminonucleoside Nephrosis.- 8. Evidence That the Anionic Sites in the Laminae Rarae of the GBM Consist of Proteoglycans Rich in Heparan Sulfate.- 9. Concluding Comments.- References.- 2 Mechanisms of Glomerular Permselectivity.- 1. Introduction.- 2. The Glomerular Capillary Wall as a Size-Selective Filter.- 3. The Glomerular Capillary Wall as a Charge-Selective Filter.- 4. Effects of Glomerular Injury on the Size-Selective and Charge-Selective Properties of the Glomerular Capillary Wall.- References.- 3 The Molecular Structure of Basement Membranes as It Relates to Function.- 1. Introduction.- 2. Morphologic Considerations.- 3. Physicochemical Properties.- 4. Biosynthesis of Basement Membrane Procollagen.- 5. Immunochemical Properties of Basement Membrane.- 6. Supramolecular Organization.- 7. Molecular Properties of Basement Membranes and StructureFunction Relationships.- 7.1. The Ultrastructural Appearance of Basement Membranes.- 7.2. Permeability Properties of Basement Membranes.- 8. Summary.- References.- 4 Glomerular Basement Membrane Antigens.- 1. Introduction.- 2. Reactivity of Rabbit Anti-GBM with Normal Kidney.- 3. Staining of Kidney with GP Renal Eluates.- 4. Preparations of Isolated GBM.- 5. Measurements of Linear Widths by Immunofluorescent Staining and Phase Microscopy.- 6. Distribution of RAHGBM and GP Antibody Staining in GBM of Diseased Kidneys.- 7. DlCT