Immunologic Signatures of Rejection [Paperback]

This book discusses the mechanisms leading to immune-mediated tissue rejection following the hypothesis that independent of the disease process the final effector mechanism is shared by most (but not all) pathologies and it is relatively simple. The book covers evidence gathered to support the thesis by studies performed in humans during rejection or in experimental models and will focus particularly (but not exclusively) on the analysis of the rejected tissue rather than the systemic circulation. Several disease processes are discussed including example of chronic inflammatory process without resolution of the pathologic process and acute one with resolution of the pathologic process (clearance of pathogen, rejection of tumor) or unwanted tissue destruction (allograft rejection, autoimmunity).

This book discusses the mechanisms leading to immune-mediated tissue rejection. It follows the hypothesis that independent of the disease process the final effector mechanism is shared by most (but not all) pathologies and it is relatively simple.

Part One - From delayed allergy reaction to the immunologic constant or rejection1. Ena Wang and Francesco M MarincolaPart Two - The immune biology of rejection; basic principles2. Experimental models of rejection  Anil Shanker A3. Cancer and Inflammation  Alberto Mantovani4. The immunologic switch  Giorgio Trinchieri5. The angiogenic switch  Douglas Noonan6. Chemokines and cytotoxic effector molecules in rejection  Alan Krensky7. Immune cell activation: the clinical perspective  David F StroncekPart Three - Circulating patterns associated with chronic and acute immune pathology8. Immune signatures detectable in peripheral lymphocytes: a modular view  Damien Chaussabel9. Immune signatures associated with unresolving compared to resolving infections: the HCV model  Robert E Lanford10. Immune signatures associated with unresolving infections: the HIV model  Luigi Buonaguro11. Immune signatures associatelG